State-dependence: an fMRI perspective

Functional Magnetic Resonance Imaging (fMRI) is a powerful tool for the non-invasive study of brain function. In recent years, an important line of research has focused on how the brain modulates its dynamics during the execution of cognitive tasks. The set of mechanisms and processes underlying the transition from the resting state to the task-oriented state is referred to in the literature as state dependence. The fMRI group at NYNLab is actively engaged in this line of research, with the aim of characterizing rest–task modulation dynamics in healthy individuals and exploring their alterations in psychiatric populations. Our translational approach seeks to integrate clinical–behavioral data with neurofunctional measures, in order to clarify the clinical impact of state-dependent mechanisms and dynamics in the human brain.